Tryptophan--tRNA ligase 2

BE0001830ProteinDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)trpS2

Catalyzes the formation of 5'adenyl-Trp and tRNA(Trp) but with 5-fold less activity than TrpRS. It is acted on by 1 drug in DrugBank.

Gene name
trpS2
UniProtKB entry
Q9RVD6Swiss-Prot
Residues / weight
351 residues · 38,179 Da
Also known as
6.1.1.2 · TrpRS 2 · TrpRS II · trpSII · Tryptophanyl-tRNA synthetase 2

Resolves to

Protein
UniProtQ9RVD6UniProt nameSYW2_DEIRA
Gene
NCBI Gene1797478GenBank6458825
Pharmacology
KEGGdra:DR_1093
Structure
PDB1YI8PDB1YIAPDB1YID
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Tryptophan--tRNA ligase 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In