Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

BE0001832ProteinHumansNMNAT3

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747, PubMed:26616331). It is acted on by 3 drugs in DrugBank.

Gene name
NMNAT3
UniProtKB entry
Q96T66Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
252 residues · 28,322 Da
Also known as
NaMN adenylyltransferase 3 · Nicotinamide-nucleotide adenylyltransferase 3 · Nicotinate-nucleotide adenylyltransferase 3 · NMN adenylyltransferase 3 · NMN/NaMN adenylyltransferase 3

Resolves to

Protein
UniProtQ96T66UniProt nameNMNA3_HUMAN
Gene
HGNCHGNC:20989NCBI Gene349565GenBank14029540GeneCardsNMNAT3
Pharmacology
KEGGhsa:349565
Structure
PDB1NUPPDB1NUQPDB1NUR
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3, and which indications are they being tested in?

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