Serine hydroxymethyltransferase

BE0001838ProteinShigella flexneriglyA

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. It is acted on by 2 drugs in DrugBank.

Gene name
glyA
UniProtKB entry
P0A827Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
417 residues · 45,316 Da
Also known as
2.1.2.1 · SHMT

Resolves to

Protein
UniProtP0A827UniProt nameGLYA_SHIFL
Gene
NCBI Gene1025638GenBank24052975
Pharmacology
KEGGsfl:SF2598
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine hydroxymethyltransferase, how selective are they, and which programs against it are still in active trials?

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