Complement factor D

BE0001840ProteinHumansCFD

Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324,... It is acted on by 5 drugs in DrugBank.

Gene name
CFD
UniProtKB entry
P00746Swiss-Prot
Cellular location
Secreted
Residues / weight
253 residues · 27,033 Da
Also known as
3.4.21.46 · Adipsin · C3 convertase activator · DF · PFD

Resolves to

Protein
UniProtP00746UniProt nameCFAD_HUMAN
Gene
HGNCHGNC:2771NCBI Gene1675GenBank178626GeneCardsCFD
Pharmacology
IUPHAR/GtoPdb2842KEGGhsa:1675
Structure
PDB1BIOPDB1DFPPDB1DIC
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Complement factor D, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In