GDP-mannose 6-dehydrogenase

BE0001849ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)algD

Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. It is acted on by 2 drugs in DrugBank.

Gene name
algD
UniProtKB entry
P11759Swiss-Prot
Residues / weight
436 residues · 47,599 Da
Also known as
1.1.1.132 · GMD · Guanosine diphospho-D-mannose dehydrogenase

Resolves to

Protein
UniProtP11759UniProt nameALGD_PSEAE
Gene
NCBI Gene879004GenBank45268
Pharmacology
KEGGpae:PA3540
Structure
PDB1MFZPDB1MUUPDB1MV8
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on GDP-mannose 6-dehydrogenase, and which indications are they being tested in?

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