Aminoglycoside 3'-phosphotransferase

BE0001858ProteinEnterococcus faecalisaphA

Resistance to kanamycin and structurally-related aminoglycosides, including amikacin. It is acted on by 1 drug in DrugBank.

Gene name
aphA
UniProtKB entry
P0A3Y5Swiss-Prot
Residues / weight
264 residues · 30,974 Da
Also known as
2.7.1.95 · APH(3')III · Kanamycin kinase, type III · Neomycin-kanamycin phosphotransferase type III

Resolves to

Protein
UniProtP0A3Y5UniProt nameKKA3_ENTFL
Gene
NCBI Gene23533821GenBank47034
Pharmacology
KEGGag:CAA24789
Structure
PDB1J7IPDB1J7LPDB1J7U
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aminoglycoside 3'-phosphotransferase, and which indications are they being tested in?

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