Mycocyclosin synthase

BE0001873ProteinMycobacterium tuberculosiscyp121

Catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. It is acted on by 2 drugs in DrugBank.

Gene name
cyp121
UniProtKB entry
P9WPP7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
396 residues · 43,255 Da
Also known as
1.14.19.70 · 1.14.21.9 · Cytochrome P450 121 · Cytochrome P450 MT2

Resolves to

Protein
UniProtP9WPP7UniProt nameCP121_MYCTU
Gene
NCBI Gene888373
Pharmacology
KEGGmtu:Rv2276
Structure
PDB1N40PDB1N4GPDB2IJ5
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mycocyclosin synthase, and which indications are they being tested in?

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