Ornithine carbamoyltransferase subunit I

BE0001875ProteinEscherichia coli (strain K12)argI

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final... It is acted on by 1 drug in DrugBank.

Gene name
argI
UniProtKB entry
P04391Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
334 residues · 36,907 Da
Also known as
2.1.3.3 · Ornithine carbamoyltransferase chain I · OTCase-1

Resolves to

Protein
UniProtP04391UniProt nameOTC1_ECOLI
Gene
NCBI Gene948774GenBank145344
Pharmacology
KEGGecj:JW4211
Structure
PDB1AKMPDB1DUVPDB2OTC
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ornithine carbamoyltransferase subunit I, and which indications are they being tested in?

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