Thymidine kinase
Details
- Name
- Thymidine kinase
- Kind
- protein
- Synonyms
- 2.7.1.21
- Gene Name
- tdk
- UniProtKB Entry
- Q9PPP5Swiss-Prot
- Organism
- Ureaplasma parvum serovar 3 (strain ATCC 700970)
- NCBI Taxonomy ID
- 273119
- Amino acid sequence
>lcl|BSEQ0011349|Thymidine kinase MAKVNAFSKKIGWIELITGPMFAGKTAELIRRLHRLEYADVKYLVFKPKIDTRSIRNIQS RTGTSLPSVEVESAPEILNYIMSNSFNDETKVIGIDEVQFFDDRICEVANILAENGFVVI ISGLDKNFKGEPFGPIAKLFTYADKITKLTAICNECGAEATHSLRKIDGKHADYNDDIVK IGCQEFYSAVCRHHHKVPNRPYLNSNSEEFIKFFKNKKRNKNI
- Number of residues
- 223
- Molecular Weight
- 25366.93
- Theoretical pI
- 8.92
- GO Classification
- FunctionsATP binding / thymidine kinase activity / zinc ion bindingProcessesDNA biosynthetic processComponentscytoplasm
- General Function
- Zinc ion binding
- Specific Function
- Not Available
- Pfam Domain Function
- TK (PF00265)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011350|Thymidine kinase (tdk) ATGGCTAAAGTGAATGCATTTTCAAAAAAAATAGGATGAATAGAATTAATTACTGGCCCA ATGTTTGCTGGAAAAACAGCAGAGTTAATTCGTCGCTTACATCGTTTAGAATATGCAGAT GTTAAATATTTGGTTTTTAAACCTAAAATTGATACTAGATCTATTAGAAATATCCAATCA CGAACAGGAACGTCTTTACCATCAGTTGAAGTAGAAAGCGCACCAGAAATTTTAAATTAT ATTATGTCAAACAGTTTTAATGATGAAACAAAAGTTATTGGCATTGATGAGGTTCAATTT TTTGATGATCGGATTTGTGAAGTTGCAAATATTTTAGCAGAAAATGGTTTTGTTGTTATT ATTTCAGGATTAGATAAAAATTTTAAAGGCGAGCCTTTTGGTCCAATTGCTAAACTTTTT ACTTATGCTGATAAAATTACAAAACTAACAGCGATATGTAATGAGTGTGGCGCTGAAGCA ACGCATTCATTGCGTAAGATTGATGGTAAACACGCTGACTATAATGATGATATTGTTAAA ATTGGCTGTCAGGAATTCTATTCTGCTGTTTGTCGTCATCATCATAAGGTACCTAATCGT CCTTATTTAAATAGTAATTCTGAGGAATTTATTAAATTTTTTAAAAATAAAAAACGAAAT AAAAATATATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9PPP5 UniProtKB Entry Name KITH_UREPA GenBank Protein ID 6899605 GenBank Gene ID AE002158 PDB ID(s) 2B8T, 2UZ3 KEGG ID uur:UU594 NCBI Gene ID 876009 - General References
- Glass JI, Lefkowitz EJ, Glass JS, Heiner CR, Chen EY, Cassell GH: The complete sequence of the mucosal pathogen Ureaplasma urealyticum. Nature. 2000 Oct 12;407(6805):757-62. [Article]
- Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu C, Wang L, Eriksson S, Munch-Petersen B, Eklund H: Structures of thymidine kinase 1 of human and mycoplasmic origin. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17970-5. Epub 2004 Dec 20. [Article]
- Kosinska U, Carnrot C, Eriksson S, Wang L, Eklund H: Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme. FEBS J. 2005 Dec;272(24):6365-72. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Thymidine 5'-triphosphate experimental unknown target Details