Phosphoheptose isomerase
Details
- Name
- Phosphoheptose isomerase
- Kind
- protein
- Synonyms
- 5.3.1.28
- Sedoheptulose 7-phosphate isomerase
- Gene Name
- gmhA
- UniProtKB Entry
- Q9HVZ0Swiss-Prot
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- NCBI Taxonomy ID
- 208964
- Amino acid sequence
>lcl|BSEQ0020572|Phosphoheptose isomerase MDMQHRIRQLFQASIETKQQALEVLPPYIEQASLVMVNALLNEGKILSCGNGGSAGDAQH FSSELLNRFERERPSLPAVALTTDSSTITSIANDYSYNEVFSKQIRALGQPGDVLLAIST SGNSANVIQAIQAAHDREMLVVALTGRDGGGMASLLLPEDVEIRVPSKITARIQEVHLLA IHCLCDLIDRQLFGSEE
- Number of residues
- 197
- Molecular Weight
- 21413.11
- Theoretical pI
- 4.72
- GO Classification
- Functionscarbohydrate binding / D-sedoheptulose 7-phosphate isomerase activity / zinc ion bindingProcessesD-glycero-D-manno-heptose 7-phosphate biosynthetic process / lipopolysaccharide core region biosynthetic processComponentscytoplasm
- General Function
- Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
- Specific Function
- carbohydrate derivative binding
- Pfam Domain Function
- SIS_2 (PF13580)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0020573|Phosphoheptose isomerase (gmhA) ATGGACATGCAACACCGTATCCGCCAGCTCTTCCAGGCCAGCATCGAGACCAAGCAGCAG GCGCTGGAAGTACTGCCTCCCTATATCGAGCAAGCCAGCCTGGTGATGGTCAATGCGCTG CTCAACGAGGGCAAGATCCTCTCCTGCGGCAATGGCGGCTCGGCCGGCGATGCCCAGCAC TTCTCCTCCGAACTGCTCAACCGCTTCGAGCGCGAACGTCCGAGCCTCCCGGCCGTGGCC CTGACCACCGACAGCTCGACCATCACCTCGATCGCCAACGACTACAGCTACAACGAAGTC TTCTCCAAGCAGATCCGCGCCCTGGGCCAGCCGGGCGACGTCCTGCTGGCGATTTCCACC AGCGGCAATTCGGCCAACGTGATCCAGGCCATCCAGGCGGCCCACGACCGCGAGATGCTG GTGGTCGCCCTGACCGGCCGCGACGGTGGCGGCATGGCTTCGCTGCTGCTGCCGGAAGAC GTGGAGATCCGCGTTCCTTCCAAGATCACCGCACGCATCCAGGAAGTCCACCTGCTGGCC ATCCACTGCCTCTGCGACCTGATCGACCGCCAACTGTTCGGGAGTGAAGAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9HVZ0 UniProtKB Entry Name GMHA_PSEAE GenBank Protein ID 9950658 GenBank Gene ID AE004091 PDB ID(s) 1X92, 3BJZ KEGG ID pae:PA4425 NCBI Gene ID 881196 - General References
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Valvano MA, Messner P, Kosma P: Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides. Microbiology. 2002 Jul;148(Pt 7):1979-89. [Article]
- Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS: Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. J Biol Chem. 2008 Feb 1;283(5):2835-45. Epub 2007 Dec 3. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-Glycero-D-Mannopyranose-7-Phosphate experimental unknown target Details