5-formyltetrahydrofolate cyclo-ligase

BE0001906ProteinMycoplasma pneumoniae (strain ATCC 29342 / M129)

Involved in folate metabolism. It is acted on by 1 drug in DrugBank.

UniProtKB entry
P75430Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
164 residues · 19,265 Da
Also known as
5,10-methenyl-tetrahydrofolate synthetase · 6.3.3.2 · Methenyl-THF synthetase · MTHFS

Resolves to

Protein
UniProtP75430UniProt nameMTHFS_MYCPN
Gene
NCBI Gene876747GenBank1674179
Pharmacology
KEGGmpn:MPN348
Structure
PDB1SBQPDB1U3FPDB1U3G
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 5-formyltetrahydrofolate cyclo-ligase, and which indications are they being tested in?

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