Gag-Pro-Pol polyprotein

Details

Name
Gag-Pro-Pol polyprotein
Kind
protein
Synonyms
  • 3.4.23.-
  • RT-beta
Gene Name
gag-pro-pol
UniProtKB Entry
Q04095Swiss-Prot
Organism
RSV-SRA
NCBI Taxonomy ID
269446
Amino acid sequence
>lcl|BSEQ0037153|Gag-Pro-Pol polyprotein
MEAVIKVISSACKTYCGKISPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQ
RAMVLGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATER
RIDKGEEVGETTAQRDAKMAPEKMATPKTVGTSCYQCGTATGCNCATASAPPPPYVGSGL
YPSLAGVGEQQGQGGDTPWGAEQPRAEPGHAGLAPGPALTDWARIREELASTGPPVVAMP
VVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAEVEALMSSPLLPHDVTNLMRVIL
GPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGRGERTNLDRLKGLADGMVGNPQGQA
ALLRPGELVAITASALQAFREVARLAEPAGPWADITQGPSESFVDFANRLIKAVEGSDLP
PSARAPVIIDCFRQKSQPDIQQLIRAAPSTLTTPGEIIKYVLDRQKIAPLTDQGIAAAMS
SAIQPLVMAVVNRERDGQTGSGGRARGLCYTCGSPGHYQAQCPKKRKSGNSRERCQLCDG
MGHNAKQCRRRDGNQGQRPGKGLSSGSWPVSEQPAVSLAMTMEHKDRPLVRVILTNTGSH
PVKQRSVYITALLDSGADITIISEEDWPTDWPVMEAANPQIHGIGGGIPMRKSRDMIEVG
VINRDGSLERPLLLFPAVAMVRGSILGRDCLQGLGLRLTNLIGRATVLTVALHLAIPLKW
KPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLH
DLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSV
NNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLRMLHYMDDLLLAASSHD
GLEAAGEEVISTLERAGFTISPDKIQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDV
QKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVQLSTTAALE
RWDPALPLEGAVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKL
RASAVRTFGKEVDILLLPACFREDLPLPEGILLALRGFAGKIRSSDTPSIFDIARPLHVS
LKVRVTDHPVPGPTAFTDASSSTHKGVVVWREGPRWEIKEIADLGASVQQLEARAVAMAL
LLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEV
PGFFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHC
NSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
AQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERAN
RLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWRPTVLTE
GPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDVTQKDEVTKKDE
ASPLFAGISDWIPWEDEQEGLQGETASNKQERPGEDTLAANES
Number of residues
1603
Molecular Weight
173931.55
Theoretical pI
8.1
GO Classification
Functions
aspartic-type endopeptidase activity / DNA binding / DNA-directed DNA polymerase activity / RNA binding / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity / structural molecule activity / zinc ion binding
Processes
DNA integration / DNA recombination / establishment of integrated proviral latency / viral entry into host cell
Components
viral capsid
General Function
Capsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro. Binds to inositol hexakisphosphate (IP6), which allows the assembly of the polyhedral capsid.
Specific Function
aspartic-type endopeptidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Virion
Gene sequence
>lcl|BSEQ0003776|2688 bp
ACTGTTGCGCTACATCTGGCTATTCCGCTCAAATGGAAGCCAGACCACACGCCTGTGTGG
ATTGACCAGTGGCCCCTTCCTGAAGGTAAACTTGTAGCGCTAACGCAATTAGTGGAAAAA
GAATTACAGTTAGGACATATAGAACCTTCACTTAGTTGTTGGAACACACCTGTCTTTGTG
ATCCGGAAGGCTTCCGGGTCTTATCGCTTATTGCATGACTTGCGCGCTGTTAACGCCAAG
CTTGTTCCTTTTGGGGCCGTCCAACAGGGGGCGCCAGTTCTCTCCGCGCTCCCGCGTGGC
TGGCCCCTGATGGTCCTAGACCTCAAGGATTGCTTCTTTTCTATTCCTCTTGCGGAACAA
GATCGCGAAGCTTTTGCATTTACGCTCCCCTCTGTGAATAACCAGGCCCCCGCTCGAAGA
TTCCAATGGAAGGTCTTGCCCCAAGGGATGACCTGTTCTCCCACTATCTGTCAGTTGGTG
GTGGGTCAGGTACTTGAGCCCTTGCGACTCAAGCACCCATCTCTGCGCATGTTGCATTAT
ATGGATGATCTTTTGCTAGCCGCCTCAAGTCATGATGGGTTGGAAGCGGCAGGGGAGGAG
GTTATCAGTACATTGGAAAGAGCCGGGTTCACCATTTCGCCTGATAAGATCCAGAGGGAA
CCCGGAGTACAATATCTTGGGTACAAGTTAGGCAGTACGTATGTAGCACCCGTAGGCCTG
GTAGCAGAACCCAGGATAGCCACCTTGTGGGATGTTCAAAAGCTGGTGGGGTCACTTCAG
TGGCTTCGCCCAGCGTTAGGAATCCCGCCACGACTGATGGGCCCCTTCTATGAGCAGTTA
CGAGGGTCAGATCCTAACGAGGCGAGGGAATGGAATCTAGACATGAAAATGGCCTGGAGA
GAGATCGTACAGCTTAGCACCACTGCTGCCTTGGAACGATGGGACCCTGCCCTGCCTTTG
GAGGGAGCGGTCGCTAGGTGTGAACAGGGGGCAATAGGGGTCCTGGGACAGGGACTGTCC
ACACACCCAAGGCCATGTTTGTGGTTATTCTCCACCCAACCCACCAAGGCGTTTACTGCT
TGGTTAGAAGTGCTCACCCTTTTGATTACTAAGCTACGCGCTTCGGCAGTGCGAACCTTT
GGCAAGGAGGTTGATATCCTCCTGTTGCCTGCATGCTTTCGGGAGGACCTTCCGCTCCCG
GAGGGGATCCTGTTAGCCCTTAGGGGGTTTGCAGGAAAAATCAGGAGTAGTGACACGCCA
TCTATTTTTGACATTGCGCGTCCACTGCATGTTTCTCTGAAAGTGAGGGTCACCGACCAC
CCTGTACCGGGACCCACTGCCTTTACCGACGCCTCCTCAAGCACCCATAAAGGGGTGGTA
GTCTGGAGGGAGGGCCCAAGGTGGGAGATAAAAGAAATAGCTGATTTGGGGGCAAGTGTA
CAACAACTGGAAGCACGCGCTGTGGCCATGGCACTTCTGCTGTGGCCGACAACGCCCACT
AATGTAGTGACTGACTCCGCGTTTGTCGCGAAAATGTTACTCAAGATGGGACAGGAGGGA
GTCCCGTCTACAGCGGCGGCTTTTATTTTAGAGGATGCGTTAAGCCAAAGGTCAGCCATG
GCCGCCGTTCTCCACGTGCGGAGTCATTCTGAAGTGCCAGGGTTTTTCACAGAAGGAAAT
GACGTGGCAGATAGCCAAGCCACCTTTCAAGCGTATCCCTTGAGAGAGGCTAAAGATCTT
CATACTGCTCTCCATATTGGACCCCGCGCGCTATCCAAAGCGTGTAATATATCTATGCAG
CAGGCTAGGGAGGTTGTTCAGACCTGCCCGCATTGTAATTCAGCCCCTGCGTTGGAGGCC
GGGGTAAACCCTAGGGGTTTGGGACCCCTACAGATATGGCAGACAGACTTTACGCTTGAG
CCTAGAATGGCCCCCCGTTCCTGGCTCGCTGTTACTGTGGATACCGCCTCATCGGCGATA
GTCGTAACTCAGCATGGCCGTGTCACATCGGTTGCTGCACAACATCATTGGGCCACGGCT
ATCGCCGTTTTGGGAAGACCAAAGGCCATAAAAACAGATAATGGGTCCTGTTTCACGTCT
AAATCCACGCGAGAGTGGCTCGCGAGATGGGGGATAGCACACACCACCGGGATTCCGGGT
AATTCCCAGGGTCAAGCTATGGTAGAGCGGGCCAACCGGCTCCTGAAAGATAAGATCCGT
GTGCTTGCGGAGGGGGACGGCTTTATGAAAAGAATCCCCACCAGCAAACAGGGGGAACTA
CTAGCCAAGGCAATGTATGCCCTCAATCACTTTGAGCGCGGTGAAAACACAAAAACACCG
ATTCAAAAACACTGGAGACCTACCGTTCTTACAGAAGGACCCCCGGTTAAAATACGAATA
GAGACAGGGGAGTGGGAAAAAGGATGGAATGTGCTGGTCTGGGGACGAGGTTATGCAGCT
GTGAAAAACAGGGACACTGATAAGGTTATTTGGGTACCCTCTCGGAAAGTTAAACCGGAT
GTCACCCAAAAGGATGAGGTGACTAAGAAAGATGAGGCGAGCCCTCTTTTTGCAGGCATT
TCTGACTGGATACCCTGGGAAGACGAGCAAGAAGGACTCCAAGGAGAAACCGCTAGCAAC
AAGCAAGAAAGACCCGGAGAAGACACCCTTGCTGCCAACGAGAGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ04095
UniProtKB Entry NamePOL_RSVSA
GenBank Protein ID210273
GenBank Gene IDM37980
General References
  1. Bieth E, Darlix JL: Complete nucleotide sequence of a highly infectious avian leukosis virus. Nucleic Acids Res. 1992 Jan 25;20(2):367. [Article]
  2. Katzman M, Katz RA, Skalka AM, Leis J: The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol. 1989 Dec;63(12):5319-27. [Article]
  3. Arad G, Bar-Meir R, Kotler M: Ribosomal frameshifting at the Gag-Pol junction in avian leukemia sarcoma virus forms a novel cleavage site. FEBS Lett. 1995 May 1;364(1):1-4. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
HydroxyethylcysteineexperimentalunknowntargetDetails