Gag-Pro-Pol polyprotein
Details
- Name
- Gag-Pro-Pol polyprotein
- Kind
- protein
- Synonyms
- 3.4.23.-
- RT-beta
- Gene Name
- gag-pro-pol
- UniProtKB Entry
- Q04095Swiss-Prot
- Organism
- RSV-SRA
- NCBI Taxonomy ID
- 269446
- Amino acid sequence
>lcl|BSEQ0037153|Gag-Pro-Pol polyprotein MEAVIKVISSACKTYCGKISPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQ RAMVLGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATER RIDKGEEVGETTAQRDAKMAPEKMATPKTVGTSCYQCGTATGCNCATASAPPPPYVGSGL YPSLAGVGEQQGQGGDTPWGAEQPRAEPGHAGLAPGPALTDWARIREELASTGPPVVAMP VVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAEVEALMSSPLLPHDVTNLMRVIL GPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGRGERTNLDRLKGLADGMVGNPQGQA ALLRPGELVAITASALQAFREVARLAEPAGPWADITQGPSESFVDFANRLIKAVEGSDLP PSARAPVIIDCFRQKSQPDIQQLIRAAPSTLTTPGEIIKYVLDRQKIAPLTDQGIAAAMS SAIQPLVMAVVNRERDGQTGSGGRARGLCYTCGSPGHYQAQCPKKRKSGNSRERCQLCDG MGHNAKQCRRRDGNQGQRPGKGLSSGSWPVSEQPAVSLAMTMEHKDRPLVRVILTNTGSH PVKQRSVYITALLDSGADITIISEEDWPTDWPVMEAANPQIHGIGGGIPMRKSRDMIEVG VINRDGSLERPLLLFPAVAMVRGSILGRDCLQGLGLRLTNLIGRATVLTVALHLAIPLKW KPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLH DLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSV NNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLRMLHYMDDLLLAASSHD GLEAAGEEVISTLERAGFTISPDKIQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDV QKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVQLSTTAALE RWDPALPLEGAVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKL RASAVRTFGKEVDILLLPACFREDLPLPEGILLALRGFAGKIRSSDTPSIFDIARPLHVS LKVRVTDHPVPGPTAFTDASSSTHKGVVVWREGPRWEIKEIADLGASVQQLEARAVAMAL LLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEV PGFFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHC NSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA AQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERAN RLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWRPTVLTE GPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDVTQKDEVTKKDE ASPLFAGISDWIPWEDEQEGLQGETASNKQERPGEDTLAANES
- Number of residues
- 1603
- Molecular Weight
- 173931.55
- Theoretical pI
- 8.1
- GO Classification
- Functionsaspartic-type endopeptidase activity / DNA binding / DNA-directed DNA polymerase activity / RNA binding / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity / structural molecule activity / zinc ion bindingProcessesDNA integration / DNA recombination / establishment of integrated proviral latency / viral entry into host cellComponentsviral capsid
- General Function
- Capsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro. Binds to inositol hexakisphosphate (IP6), which allows the assembly of the polyhedral capsid.
- Specific Function
- aspartic-type endopeptidase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0003776|2688 bp ACTGTTGCGCTACATCTGGCTATTCCGCTCAAATGGAAGCCAGACCACACGCCTGTGTGG ATTGACCAGTGGCCCCTTCCTGAAGGTAAACTTGTAGCGCTAACGCAATTAGTGGAAAAA GAATTACAGTTAGGACATATAGAACCTTCACTTAGTTGTTGGAACACACCTGTCTTTGTG ATCCGGAAGGCTTCCGGGTCTTATCGCTTATTGCATGACTTGCGCGCTGTTAACGCCAAG CTTGTTCCTTTTGGGGCCGTCCAACAGGGGGCGCCAGTTCTCTCCGCGCTCCCGCGTGGC TGGCCCCTGATGGTCCTAGACCTCAAGGATTGCTTCTTTTCTATTCCTCTTGCGGAACAA GATCGCGAAGCTTTTGCATTTACGCTCCCCTCTGTGAATAACCAGGCCCCCGCTCGAAGA TTCCAATGGAAGGTCTTGCCCCAAGGGATGACCTGTTCTCCCACTATCTGTCAGTTGGTG GTGGGTCAGGTACTTGAGCCCTTGCGACTCAAGCACCCATCTCTGCGCATGTTGCATTAT ATGGATGATCTTTTGCTAGCCGCCTCAAGTCATGATGGGTTGGAAGCGGCAGGGGAGGAG GTTATCAGTACATTGGAAAGAGCCGGGTTCACCATTTCGCCTGATAAGATCCAGAGGGAA CCCGGAGTACAATATCTTGGGTACAAGTTAGGCAGTACGTATGTAGCACCCGTAGGCCTG GTAGCAGAACCCAGGATAGCCACCTTGTGGGATGTTCAAAAGCTGGTGGGGTCACTTCAG TGGCTTCGCCCAGCGTTAGGAATCCCGCCACGACTGATGGGCCCCTTCTATGAGCAGTTA CGAGGGTCAGATCCTAACGAGGCGAGGGAATGGAATCTAGACATGAAAATGGCCTGGAGA GAGATCGTACAGCTTAGCACCACTGCTGCCTTGGAACGATGGGACCCTGCCCTGCCTTTG GAGGGAGCGGTCGCTAGGTGTGAACAGGGGGCAATAGGGGTCCTGGGACAGGGACTGTCC ACACACCCAAGGCCATGTTTGTGGTTATTCTCCACCCAACCCACCAAGGCGTTTACTGCT TGGTTAGAAGTGCTCACCCTTTTGATTACTAAGCTACGCGCTTCGGCAGTGCGAACCTTT GGCAAGGAGGTTGATATCCTCCTGTTGCCTGCATGCTTTCGGGAGGACCTTCCGCTCCCG GAGGGGATCCTGTTAGCCCTTAGGGGGTTTGCAGGAAAAATCAGGAGTAGTGACACGCCA TCTATTTTTGACATTGCGCGTCCACTGCATGTTTCTCTGAAAGTGAGGGTCACCGACCAC CCTGTACCGGGACCCACTGCCTTTACCGACGCCTCCTCAAGCACCCATAAAGGGGTGGTA GTCTGGAGGGAGGGCCCAAGGTGGGAGATAAAAGAAATAGCTGATTTGGGGGCAAGTGTA CAACAACTGGAAGCACGCGCTGTGGCCATGGCACTTCTGCTGTGGCCGACAACGCCCACT AATGTAGTGACTGACTCCGCGTTTGTCGCGAAAATGTTACTCAAGATGGGACAGGAGGGA GTCCCGTCTACAGCGGCGGCTTTTATTTTAGAGGATGCGTTAAGCCAAAGGTCAGCCATG GCCGCCGTTCTCCACGTGCGGAGTCATTCTGAAGTGCCAGGGTTTTTCACAGAAGGAAAT GACGTGGCAGATAGCCAAGCCACCTTTCAAGCGTATCCCTTGAGAGAGGCTAAAGATCTT CATACTGCTCTCCATATTGGACCCCGCGCGCTATCCAAAGCGTGTAATATATCTATGCAG CAGGCTAGGGAGGTTGTTCAGACCTGCCCGCATTGTAATTCAGCCCCTGCGTTGGAGGCC GGGGTAAACCCTAGGGGTTTGGGACCCCTACAGATATGGCAGACAGACTTTACGCTTGAG CCTAGAATGGCCCCCCGTTCCTGGCTCGCTGTTACTGTGGATACCGCCTCATCGGCGATA GTCGTAACTCAGCATGGCCGTGTCACATCGGTTGCTGCACAACATCATTGGGCCACGGCT ATCGCCGTTTTGGGAAGACCAAAGGCCATAAAAACAGATAATGGGTCCTGTTTCACGTCT AAATCCACGCGAGAGTGGCTCGCGAGATGGGGGATAGCACACACCACCGGGATTCCGGGT AATTCCCAGGGTCAAGCTATGGTAGAGCGGGCCAACCGGCTCCTGAAAGATAAGATCCGT GTGCTTGCGGAGGGGGACGGCTTTATGAAAAGAATCCCCACCAGCAAACAGGGGGAACTA CTAGCCAAGGCAATGTATGCCCTCAATCACTTTGAGCGCGGTGAAAACACAAAAACACCG ATTCAAAAACACTGGAGACCTACCGTTCTTACAGAAGGACCCCCGGTTAAAATACGAATA GAGACAGGGGAGTGGGAAAAAGGATGGAATGTGCTGGTCTGGGGACGAGGTTATGCAGCT GTGAAAAACAGGGACACTGATAAGGTTATTTGGGTACCCTCTCGGAAAGTTAAACCGGAT GTCACCCAAAAGGATGAGGTGACTAAGAAAGATGAGGCGAGCCCTCTTTTTGCAGGCATT TCTGACTGGATACCCTGGGAAGACGAGCAAGAAGGACTCCAAGGAGAAACCGCTAGCAAC AAGCAAGAAAGACCCGGAGAAGACACCCTTGCTGCCAACGAGAGTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q04095 UniProtKB Entry Name POL_RSVSA GenBank Protein ID 210273 GenBank Gene ID M37980 - General References
- Bieth E, Darlix JL: Complete nucleotide sequence of a highly infectious avian leukosis virus. Nucleic Acids Res. 1992 Jan 25;20(2):367. [Article]
- Katzman M, Katz RA, Skalka AM, Leis J: The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol. 1989 Dec;63(12):5319-27. [Article]
- Arad G, Bar-Meir R, Kotler M: Ribosomal frameshifting at the Gag-Pol junction in avian leukemia sarcoma virus forms a novel cleavage site. FEBS Lett. 1995 May 1;364(1):1-4. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Hydroxyethylcysteine experimental unknown target Details