Cathepsin L2
Details
- Name
- Cathepsin L2
- Kind
- protein
- Synonyms
- 3.4.22.43
- Cathepsin U
- Cathepsin V
- CATL2
- CTSL2
- CTSU
- Gene Name
- CTSV
- UniProtKB Entry
- O60911Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0020577|Cathepsin L2 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
- Number of residues
- 334
- Molecular Weight
- 37329.215
- Theoretical pI
- 9.0
- GO Classification
- Functionscysteine-type endopeptidase activator activity involved in apoptotic process / serine-type endopeptidase activityProcessesimmune response / positive regulation of apoptotic signaling pathway / proteolysis involved in protein catabolic process
- General Function
- Cysteine protease. May have an important role in corneal physiology
- Specific Function
- cysteine-type endopeptidase activator activity involved in apoptotic process
- Pfam Domain Function
- Signal Regions
- 1-17
- Transmembrane Regions
- Not Available
- Cellular Location
- Lysosome
- Gene sequence
>lcl|BSEQ0020578|Cathepsin L2 (CTSV) ATGAATCTTTCGCTCGTCCTGGCTGCCTTTTGCTTGGGAATAGCCTCCGCTGTTCCAAAA TTTGACCAAAATTTGGATACAAAGTGGTACCAGTGGAAGGCAACACACAGAAGATTATAT GGCGCGAATGAAGAAGGATGGAGGAGAGCAGTGTGGGAAAAGAATATGAAAATGATTGAA CTGCACAATGGGGAATACAGCCAAGGGAAACATGGCTTCACAATGGCCATGAATGCTTTT GGTGACATGACCAATGAAGAATTCAGGCAGATGATGGGTTGCTTTCGAAACCAGAAATTC AGGAAGGGGAAAGTGTTCCGTGAGCCTCTGTTTCTTGATCTTCCCAAATCTGTGGATTGG AGAAAGAAAGGCTACGTGACGCCAGTGAAGAATCAGAAACAGTGTGGTTCTTGTTGGGCT TTTAGTGCGACTGGTGCTCTTGAAGGACAGATGTTCCGGAAAACTGGGAAACTTGTCTCA CTGAGCGAGCAGAATCTGGTGGACTGTTCGCGTCCTCAAGGCAATCAGGGCTGCAATGGT GGCTTCATGGCTAGGGCCTTCCAGTATGTCAAGGAGAACGGAGGCCTGGACTCTGAGGAA TCCTATCCATATGTAGCAGTGGATGAAATCTGTAAGTACAGACCTGAGAATTCTGTTGCT AATGACACTGGCTTCACAGTGGTCGCACCTGGAAAGGAGAAGGCCCTGATGAAAGCAGTC GCAACTGTGGGGCCCATCTCCGTTGCTATGGATGCAGGCCATTCGTCCTTCCAGTTCTAC AAATCAGGCATTTATTTTGAACCAGACTGCAGCAGCAAAAACCTGGATCATGGTGTTCTG GTGGTTGGCTACGGCTTTGAAGGAGCAAATTCGAATAACAGCAAGTATTGGCTCGTCAAA AACAGCTGGGGTCCAGAATGGGGCTCGAATGGCTATGTAAAAATAGCCAAAGACAAGAAC AACCACTGTGGAATCGCCACAGCAGCCAGCTACCCCAATGTGTGA
- Chromosome Location
- 9
- Locus
- 9q22.33
- External Identifiers
Resource Link UniProtKB ID O60911 UniProtKB Entry Name CATL2_HUMAN GenBank Protein ID 3087790 GenBank Gene ID Y14734 GeneCard ID CTSV GenAtlas ID CTSL2 HGNC ID HGNC:2538 PDB ID(s) 1FH0, 3H6S, 3KFQ, 7PK4, 7Q8D, 7Q8F, 7Q8G, 7Q8H, 7Q8I, 7Q8J, 7Q8K, 7Q8L, 7Q8M, 7Q8N, 7Q8O, 7Q8P, 7Q8Q, 7Q9H, 7QFF, 7QFH, 7QGW, 7QHJ, 7QHK, 7QNS, 7QO2 KEGG ID hsa:1515 IUPHAR/Guide To Pharmacology ID 2352 NCBI Gene ID 1515 - General References
- Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C: Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. Cancer Res. 1998 Apr 15;58(8):1624-30. [Article]
- Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K: Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. Invest Ophthalmol Vis Sci. 1998 Sep;39(10):1789-96. [Article]
- Bromme D, Li Z, Barnes M, Mehler E: Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. Biochemistry. 1999 Feb 23;38(8):2377-85. [Article]
- Itoh R, Kawamoto S, Adachi W, Kinoshita S, Okubo K: Genomic organization and chromosomal localization of the human cathepsin L2 gene. DNA Res. 1999 Apr 30;6(2):137-40. [Article]
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [Article]
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- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Niwa Y, Suzuki T, Dohmae N, Umezawa K, Simizu S: Determination of cathepsin V activity and intracellular trafficking by N-glycosylation. FEBS Lett. 2012 Oct 19;586(20):3601-7. doi: 10.1016/j.febslet.2012.08.001. Epub 2012 Aug 9. [Article]
- Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
- Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME: Crystal structure of human cathepsin V. Biochemistry. 2000 Oct 17;39(41):12543-51. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 3-amino-5-phenylpentane experimental unknown target Details 4-Methylpiperazin-1-Yl Carbonyl Group experimental unknown target Details