Uracil-DNA glycosylase

BE0001918ProteinHHV-1

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. It is acted on by 1 drug in DrugBank.

UniProtKB entry
P10186Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
334 residues · 36,328 Da
Also known as
3.2.2.27 · UDG · UNG

Resolves to

Protein
UniProtP10186UniProt nameUNG_HHV11
Gene
NCBI Gene2703370GenBank59502
Pharmacology
KEGGvg:2703370
Structure
PDB1LAUPDB1UDGPDB1UDH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Uracil-DNA glycosylase, and which indications are they being tested in?

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