Ribonuclease PH

BE0001919ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)rph

Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. It is acted on by 1 drug in DrugBank.

Gene name
rph
UniProtKB entry
P50597Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
239 residues · 25,654 Da
Also known as
2.7.7.56 · RNase PH · tRNA nucleotidyltransferase

Resolves to

Protein
UniProtP50597UniProt nameRNPH_PSEAE
Gene
NCBI Gene878218GenBank1079663
Pharmacology
KEGGpae:PA5334
Structure
PDB1R6LPDB1R6M
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ribonuclease PH, and which indications are they being tested in?

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