Threonine--tRNA ligase
Details
- Name
- Threonine--tRNA ligase
- Kind
- protein
- Synonyms
- 6.1.1.3
- Threonyl-tRNA synthetase
- ThrRS
- Gene Name
- thrS
- UniProtKB Entry
- Q8NW68Swiss-Prot
- Organism
- Staphylococcus aureus (strain MW2)
- NCBI Taxonomy ID
- 196620
- Amino acid sequence
>lcl|BSEQ0011382|Threonine--tRNA ligase MEQINIQFPDGNKKAFDKGTTTEDIAQSISPGLRKKAVAGKFNGQLVDLTKPLETDGSIE IVTPGSEEALEVLRHSTAHLMAHAIKRLYGNVKFGVGPVIEGGFYYDFDIDQNISSDDFE QIEKTMKQIVNENMKIERKVVSRDEAKELFSNDEYKLELIDAIPEDENVTLYSQGDFTDL CRGVHVPSTAKIKEFKLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQMLEERKE RDHRKIGKELELFTNSQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLAN VDLYKTSGHWDHYQEDMFPPMQLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRIAEL GTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSF RLSYRDPEDKEKYFDDDDMWNKAENMLKEAADELGLSYEEAIGEAAFYGPKLDVQVKTAM GKEETLSTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSTMERFVAFLTEETKGAFP TWLAPKQVQIIPVNVDLHYDYARQLQDELKSQGVRVSIDDRNEKMGYKIREAQMQKIPYQ IVVGDKEVENNQVNVRQYGSQDQETVEKDEFIWNLVDEIRLKKHR
- Number of residues
- 645
- Molecular Weight
- 74459.78
- Theoretical pI
- 5.04
- GO Classification
- FunctionsATP binding / metal ion binding / threonine-tRNA ligase activityProcessesthreonyl-tRNA aminoacylationComponentscytoplasm
- General Function
- Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0003808|1938 bp CTATCTATGTTTTTTTAAACGAATTTCATCAACTAGATTCCAGATAAATTCATCTTTTTC AACTGTTTCTTGGTCTTGCGATCCATATTGACGCACATTCACTTGATTATTTTCAACTTC CTTATCCCCAACTACGATTTGATAAGGTATTTTTTGCATTTGAGCTTCTCTAATTTTATA ACCCATTTTTTCATTACGGTCATCAATACTTACACGAACGCCTTGAGATTTCAATTCATC TTGTAATTGGCGCGCATAATCATAATGTAAATCAACGTTAACTGGAATGATTTGAACTTG TTTTGGCGCTAACCAAGTTGGGAATGCACCTTTAGTTTCTTCAGTTAAAAATGCTACAAA TCGTTCCATTGTTGATACAACACCACGATGAATAACAACTGGACGATGATGTTCACCATC TTGACCAATATAAGTTAAATCAAAACGTTCTGGTAATAAGAAATCAAGTTGTGCTGTTGA TAATGTCTCTTCTTTACCCATCGCTGTTTTAACTTGAACATCTAGTTTCGGACCATAGAA TGCCGCTTCACCAATCGCTTCTTCGTACGATAAGCCAAGCTCATCCGCTGCCTCTTTAAG CATATTTTCAGCTTTATTCCACATATCATCATCATCAAAGTACTTTTCTTTATCTTCAGG GTCTCTATAACTTAATCTAAAGCTATAATCCTCGAAACCAAAGTCTTTATACACATCAAT AATCATGTTTACAACGCGTTTGAATTCTTCTTTAATTTGATCAGGTCGAACAAAGATATG TGAATCATTTAAAGTCATACCACGAACACGTTGTAATCCTGATACAGCACCACTTGCTTC ATATCTATGCATCGTTCCTAGCTCAGCGATACGGATAGGTAATTCACGATATGAATGTGG TTTATTCGCATAAATCATCATATGATGTGGACAGTTCATTGGACGTAATACCATAGATTC AGTTTCATCTAACTGCATTGGTGGGAACATATCTTCTTGATAGTGATCCCAGTGACCAGA TGTTTTGTATAAATCAACATTAGCAAGTACTGGTGTATAAACGTGGTCATACCCCATGCT CACCTCTTTATCAACAATGTAACGTTCAATTTCACGTCTAATTGTTGCACCGTTAGGTAA CCATAATGGCAAACCAGCACCAACTAATTGGCTATTTGTGAATAATTCTAACTCTTTACC AATTTTACGATGATCACGTTCTTTACGCTCTTCTAACATTTGTAAATGTGCTTTTAATTC TTTTTTATCAAAGAAAGCAGTACCGTATATACGTTGTAACATTTTGTTGTTACTATCTCC ACGCCAGTATGCACCTGCTGTAGATAATAGTTTAAACTCTTTAATTTTAGCTGTTGATGG AACGTGAACTCCACGACATAAATCAGTAAAATCACCTTGACTATATAATGTTACATTTTC ATCTTCAGGAATCGCGTCGATTAATTCTAATTTGTATTCATCATTGCTGAATAACTCTTT CGCTTCATCTCGTGAAACCACTTTTCGTTCGATTTTCATATTTTCGTTAACGATTTGTTT CATTGTCTTTTCAATTTGTTCAAAGTCATCAGATGAGATGTTTTGGTCAATGTCGAAGTC ATAGTAGAATCCACCTTCTATTACAGGACCTACACCAAATTTAACATTACCATATAACCT TTTAATCGCGTGTGCCATTAAATGTGCAGTAGAATGACGTAATACCTCTAACGCTTCTTC ACTACCTGGTGTCACAATTTCAATTGATCCATCAGTTTCAAGCGGTTTTGTTAAATCTAC AAGTTGCCCGTTAAATTTGCCGGCAACAGCTTTTTTACGTAATCCAGGACTAATTGATTG TGCTATATCTTCAGTAGTAGTACCTTTATCAAACGCCTTTTTATTACCATCTGGAAATTG AATATTAATTTGTTCCAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8NW68 UniProtKB Entry Name SYT_STAAW GenBank Protein ID 21204795 GenBank Gene ID BA000033 PDB ID(s) 1NYQ, 1NYR NCBI Gene ID 23197476 - General References
- Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K: Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002 May 25;359(9320):1819-27. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 5'-O-(L-Threonylsulfamoyl)adenosine experimental unknown target Details