Threonine--tRNA ligase

BE0001923ProteinStaphylococcus aureus (strain MW2)thrS

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). It is acted on by 1 drug in DrugBank.

Gene name
thrS
UniProtKB entry
Q8NW68Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
645 residues · 74,460 Da
Also known as
6.1.1.3 · Threonyl-tRNA synthetase · ThrRS

Resolves to

Protein
UniProtQ8NW68UniProt nameSYT_STAAW
Gene
NCBI Gene23197476GenBank21204795
Structure
PDB1NYQPDB1NYR
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Threonine--tRNA ligase, and which indications are they being tested in?

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