Ribonuclease 4
Details
- Name
- Ribonuclease 4
- Kind
- protein
- Synonyms
- 3.1.27.-
- RNase 4
- RNS4
- Gene Name
- RNASE4
- UniProtKB Entry
- P34096Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0016614|Ribonuclease 4 MALQRTHSLLLLLLLTLLGLGLVQPSYGQDGMYQRFLRQHVHPEETGGSDRYCNLMMQRR KMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNC RYRAIASTRRVVIACEGNPQVPVHFDG
- Number of residues
- 147
- Molecular Weight
- 16840.37
- Theoretical pI
- 9.17
- GO Classification
- FunctionsRNA nuclease activityProcessesantibacterial humoral response / defense response to Gram-positive bacteriumComponentsextracellular space
- General Function
- Cleaves preferentially after uridine bases (PubMed:3467790). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:33818125). Probably contributes to urinary tract sterility (PubMed:33818125)
- Specific Function
- nucleic acid binding
- Pfam Domain Function
- RnaseA (PF00074)
- Signal Regions
- 1-28
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016615|Ribonuclease 4 (RNASE4) ATGGCTCTGCAGAGGACCCATTCATTGCTTCTGCTTTTGCTGCTGACCCTGCTGGGGCTG GGGCTGGTCCAGCCCTCCTATGGCCAGGATGGCATGTACCAGCGATTCCTGCGGCAACAC GTGCACCCTGAGGAGACAGGTGGCAGTGATCGCTACTGCAACTTGATGATGCAAAGACGG AAGATGACTTTGTATCACTGCAAGCGCTTCAACACCTTCATCCATGAAGATATCTGGAAC ATTCGTAGTATCTGCAGCACCACCAATATCCAATGCAAGAACGGCAAGATGAACTGCCAT GAGGGTGTAGTGAAGGTCACAGATTGCAGGGACACAGGAAGTTCCAGGGCACCCAACTGC AGATATCGGGCCATAGCGAGCACTAGACGTGTTGTCATTGCCTGTGAGGGTAACCCACAG GTGCCTGTGCACTTTGACGGTTAG
- Chromosome Location
- 14
- Locus
- 14q11.2
- External Identifiers
Resource Link UniProtKB ID P34096 UniProtKB Entry Name RNAS4_HUMAN GenBank Protein ID 976229 GenBank Gene ID D37931 GeneCard ID RNASE4 GenAtlas ID RNASE4 HGNC ID HGNC:10047 PDB ID(s) 1RNF, 2RNF KEGG ID hsa:6038 NCBI Gene ID 6038 - General References
- Seno M, Futami J, Tsushima Y, Akutagawa K, Kosaka M, Tada H, Yamada H: Molecular cloning and expression of human ribonuclease 4 cDNA. Biochim Biophys Acta. 1995 Apr 26;1261(3):424-6. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Rosenberg HF, Dyer KD: Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. Nucleic Acids Res. 1995 Nov 11;23(21):4290-5. [Article]
- Zhou HM, Strydom DJ: The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. Eur J Biochem. 1993 Oct 1;217(1):401-10. [Article]
- Shapiro R, Fett JW, Strydom DJ, Vallee BL: Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. Biochemistry. 1986 Nov 18;25(23):7255-64. [Article]
- Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Ruth FX, Coll M: The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J Mol Biol. 1999 Jan 8;285(1):205-14. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2'-Deoxyuridine 3'-Monophosphate experimental unknown target Details