Aspartate carbamoyltransferase catalytic subunit

BE0001928ProteinShigella flexneripyrB

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway. It is acted on by 1 drug in DrugBank.

Gene name
pyrB
UniProtKB entry
P0A789Swiss-Prot
Residues / weight
311 residues · 34,427 Da
Also known as
2.1.3.2 · Aspartate carbamoyltransferase catalytic chain · Aspartate transcarbamylase · ATCase

Resolves to

Protein
UniProtP0A789UniProt namePYRB_SHIFL
Gene
NCBI Gene1026558GenBank24054763
Pharmacology
KEGGsfl:SF4245
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aspartate carbamoyltransferase catalytic subunit, and which indications are they being tested in?

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