Outer membrane protein TolC

BE0001931ProteinEscherichia coli (strain K12)tolC

Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. It is acted on by 2 drugs in DrugBank.

Gene name
tolC
UniProtKB entry
P02930Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
493 residues · 53,740 Da
Also known as
colE1-i · mtcB · mukA · Multidrug efflux pump subunit TolC · Outer membrane factor TolC

Resolves to

Protein
UniProtP02930UniProt nameTOLC_ECOLI
Gene
NCBI Gene947521GenBank43107
Pharmacology
KEGGecj:JW5503
Structure
PDB1EK9PDB1TQQPDB2VDD
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
25+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Outer membrane protein TolC, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In