Thymidylate kinase
Details
- Name
- Thymidylate kinase
- Kind
- protein
- Synonyms
- 2.7.4.9
- dTMP kinase
- Thymidine monophosphate kinase
- TMPK
- Gene Name
- tmk
- UniProtKB Entry
- P0A721Swiss-Prot
- Organism
- Shigella flexneri
- NCBI Taxonomy ID
- 623
- Amino acid sequence
>lcl|BSEQ0011391|Thymidylate kinase MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSV GDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHML ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ DKSIHTIDATQPLEAVMDAIRTTVTHWVKELDA
- Number of residues
- 213
- Molecular Weight
- 23782.93
- Theoretical pI
- 5.16
- GO Classification
- FunctionsATP binding / thymidylate kinase activityProcessesdTDP biosynthetic process / dTTP biosynthetic process
- General Function
- Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth (By similarity).
- Specific Function
- ATP binding
- Pfam Domain Function
- Thymidylate_kin (PF02223)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011392|Thymidylate kinase (tmk) ATGCGCAGTAAGTATATCGTCATTGAGGGGCTGGAAGGCGCAGGCAAAACTACCGCGCGT AATGTGGTGGTTGAGACGCTCGAGCAACTGGGTATCCGCGACATGGTTTTCACTCGGGAA CCTGGCGGTACGCAACTTGCCGAAAAGTTAAGAAGCCTGGTGCTGGATATCAAATCGGTA GGCGATGAAGTCATTACCGATAAAGCCGAAGTTCTGATGTTTTATGCCGCGCGCGTTCAA CTGGTAGAAACGGTCATCAAACCTGCGCTGGCTAACGGCACCTGGGTGATTGGCGATCGC CACGATCTTTCCACTCAGGCGTATCAGGGCGGAGGACGTGGTATTGACCAACATATGCTG GCAACACTGCGTGATGCTGTTCTCGGGGATTTTCGCCCAGACTTAACGCTCTATCTCGAT GTTACCCCGGAAGTTGGCTTAAAACGCGCGCGTGCGCGCGGCGAGCTGGATCGTATTGAG CAAGAGTCTTTCGATTTCTTTAATCGCACCCGCGCCCGCTATCTGGAACTGGCTGCACAA GATAAAAGTATTCATACCATTGATGCCACCCAGCCGCTGGAGGCCGTGATGGATGCAATC CGCACTACCGTGACCCACTGGGTGAAGGAGTTGGACGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A721 UniProtKB Entry Name KTHY_SHIFL GenBank Protein ID 24051392 GenBank Gene ID AE005674 KEGG ID sfl:SF1102 NCBI Gene ID 1024058 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate experimental unknown target ligand Details