Sensor histidine kinase CitA
Details
- Name
- Sensor histidine kinase CitA
- Kind
- protein
- Synonyms
- 2.7.13.3
- Gene Name
- citA
- UniProtKB Entry
- P52687Swiss-Prot
- Organism
- Klebsiella pneumoniae
- NCBI Taxonomy ID
- 573
- Amino acid sequence
>lcl|BSEQ0016619|Sensor histidine kinase CitA MSIYPMYTRKITHWFARRSFQNRIFLLILFTSTIVMLAMSWYLTDITEERLHYQVGQRAL IQAMQISAMPELVEAVQKRDLARIKALIDPMRSFSDATYITVGDASGQRLYHVNPDEIGK SMEGGDSDEALINAKSYVSVRKGSLGSSLRGKSPIQDATGKVIGIVSVGYTIEQLENWLS LQISSLLIPMAIMLLLLLFCARRFSLHIKKQMLNMEPQQLSQLLIQQSVLFESVFEGLIA IDSDYKITAINQTARRLLNLSQPEPTLIGKRISSVISQEVFFYDAPQTNKKDEIVTFNQI KVIASRMAVILNNEPQGWVISFRSKDDINTLSLQLSQVQQYADNLRAVQHEHRNLISTIA GLLFLKRYNQALELIQQQSESHQKVIDFIARNFQDNHLAGLLIGKYYRAKELGLELIFDP ACFVDRLPTALSHNEWISIVGNLLDNAYNASLRQPQGSKQIECLINSDGQEVIIEIADQG CGIDEALRDRIFERGVTSSASKDHGIGLWLVRSYVEQAGGSIVVENNIPFGTIFTLYIPL TRDEHHG
- Number of residues
- 547
- Molecular Weight
- 61779.46
- Theoretical pI
- 6.8
- GO Classification
- FunctionsATP binding / phosphorelay sensor kinase activityComponentsintegral component of membrane / intracellular / plasma membrane
- General Function
- Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes.
- Specific Function
- ATP binding
- Pfam Domain Function
- Cache_3 (PF14827)
- Signal Regions
- Not Available
- Transmembrane Regions
- 24-44 181-201
- Cellular Location
- Cell inner membrane
- Gene sequence
>lcl|BSEQ0003844|1644 bp ATGTCTATCTACCCAATGTATACCCGAAAAATCACCCACTGGTTTGCCAGGCGATCGTTT CAGAATCGCATCTTCCTGCTGATCTTATTCACCTCGACGATCGTCATGCTGGCGATGTCA TGGTATCTGACAGACATTACCGAGGAGCGTCTGCATTATCAGGTCGGGCAACGGGCGCTG ATTCAGGCGATGCAGATTTCGGCGATGCCGGAGCTGGTGGAGGCAGTGCAGAAACGCGAT CTCGCCAGAATCAAAGCCCTTATCGACCCCATGCGTTCGTTCTCCGACGCCACCTACATC ACCGTCGGTGATGCCAGCGGCCAGCGCCTCTATCACGTCAATCCTGATGAAATCGGCAAA TCGATGGAAGGCGGCGATAGCGATGAGGCGTTGATAAACGCTAAAAGCTACGTGTCAGTG CGCAAAGGCTCGCTGGGATCGTCGCTGCGCGGTAAATCGCCGATTCAGGACGCAACCGGC AAGGTGATCGGCATTGTGTCGGTAGGCTATACCATTGAGCAACTGGAAAACTGGCTCAGC CTGCAGATAAGTTCGCTGCTGATCCCGATGGCCATCATGTTACTGCTTCTGCTCTTTTGC GCCCGCCGCTTCTCACTGCATATCAAAAAACAGATGCTCAATATGGAACCCCAGCAGCTG TCACAGCTGTTGATCCAGCAAAGCGTGCTGTTTGAATCGGTGTTCGAAGGGCTTATCGCC ATCGACTCCGATTATAAAATCACTGCGATTAATCAGACTGCGCGTCGCCTGCTCAATTTG AGTCAGCCGGAACCGACGCTTATCGGCAAACGGATCAGCAGCGTTATCTCGCAGGAGGTC TTCTTCTACGATGCGCCACAGACCAATAAAAAAGACGAGATCGTTACCTTCAATCAGATC AAAGTGATCGCCAGCCGGATGGCGGTGATCTTAAACAATGAGCCACAGGGCTGGGTGATC AGCTTTCGCAGCAAAGACGATATCAACACCCTTAGCCTGCAGCTTAGCCAGGTACAACAA TATGCCGATAACCTGCGCGCCGTACAGCATGAGCATCGCAATCTGATCTCCACTATCGCC GGTCTGCTGTTTCTTAAACGCTATAACCAAGCGCTGGAACTTATCCAACAGCAGTCGGAA AGTCACCAGAAGGTGATCGATTTTATTGCACGCAATTTCCAGGACAACCACCTGGCCGGG CTGTTGATCGGCAAATATTACCGGGCCAAAGAGCTTGGACTTGAGCTGATTTTCGATCCG GCCTGCTTCGTTGATAGATTACCTACCGCCCTTTCGCACAACGAATGGATCTCGATCGTG GGGAATCTACTTGATAACGCCTACAATGCCAGCCTGCGTCAACCGCAGGGTTCAAAACAG ATCGAATGCCTGATCAACAGTGATGGCCAGGAGGTGATCATTGAGATCGCCGACCAGGGA TGCGGCATTGACGAGGCGCTGCGCGATCGGATCTTCGAGCGCGGCGTCACCAGCAGCGCC AGCAAAGATCATGGTATCGGACTCTGGCTAGTACGCAGCTACGTGGAACAAGCAGGCGGC AGTATCGTCGTCGAAAATAATATTCCTTTTGGCACCATTTTTACGCTTTATATCCCCCTG ACCCGAGATGAACATCATGGATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P52687 UniProtKB Entry Name CITA_KLEPN GenBank Protein ID 924991 GenBank Gene ID U31464 PDB ID(s) 1P0Z, 2J80, 2V9A - General References
- Bott M, Meyer M, Dimroth P: Regulation of anaerobic citrate metabolism in Klebsiella pneumoniae. Mol Microbiol. 1995 Nov;18(3):533-46. [Article]
- Kaspar S, Perozzo R, Reinelt S, Meyer M, Pfister K, Scapozza L, Bott M: The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor. Mol Microbiol. 1999 Aug;33(4):858-72. [Article]
- Gerharz T, Reinelt S, Kaspar S, Scapozza L, Bott M: Identification of basic amino acid residues important for citrate binding by the periplasmic receptor domain of the sensor kinase CitA. Biochemistry. 2003 May 20;42(19):5917-24. [Article]
- Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR: The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain. J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Heptamolybdate experimental unknown target Details Dihydroxy(oxo)molybdenum(6+) experimental unknown target Details