Dihydrofolate reductase

BE0001944ProteinMycobacterium tuberculosisfolA

Key enzyme in folate metabolism. It is acted on by 3 drugs in DrugBank.

Gene name
folA
UniProtKB entry
P9WNX1Swiss-Prot
Residues / weight
161 residues · 17,872 Da
Also known as
1.5.1.3 · dfrA

Resolves to

Protein
UniProtP9WNX1UniProt nameDYR_MYCTU
Gene
NCBI Gene887777
Pharmacology
KEGGmtu:Rv2763c
Structure
PDB1DF7PDB1DG5PDB1DG7
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
9+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Dihydrofolate reductase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In