DNA topoisomerase 1

BE0001950ProteinEscherichia coli (strain K12)topA

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. It is acted on by 3 drugs in DrugBank.

Gene name
topA
UniProtKB entry
P06612Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
865 residues · 97,349 Da
Also known as
5.6.2.1 · 5.99.1.2 · DNA topoisomerase I · Omega-protein · Relaxing enzyme

Resolves to

Protein
UniProtP06612UniProt nameTOP1_ECOLI
Gene
NCBI Gene945862GenBank415338
Pharmacology
KEGGecj:JW1266
Structure
PDB1CY0PDB1CY1PDB1CY2
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
20+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on DNA topoisomerase 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In