Capsid scaffolding protein
Details
- Name
- Capsid scaffolding protein
- Kind
- protein
- Synonyms
- Capsid protein P40
- pPR
- Protease precursor
- Protein EC-RF3/EC-RF3A
- Virion structural protein BVRF2
- Gene Name
- Not Available
- UniProtKB Entry
- P03234Swiss-Prot
- Organism
- HHV-4
- NCBI Taxonomy ID
- 10377
- Amino acid sequence
>lcl|BSEQ0003881|Capsid scaffolding protein MVQAPSVYVCGFVERPDAPPKDACLHLDPLTVKSQLPLKKPLPLTVEHLPDAPVGSVFGL YQSRAGLFSAASITSGDFLSLLDSIYHDCDIAQSQRLPLPREPKVEALHAWLPSLSLASL HPDIPQTTADGGKLSFFDHVSICALGRRRGTTAVYGTDLAWVLKHFSDLEPSIAAQIEND ANAAKRESGCPEDHPLPLTKLIAKAIDAGFLRNRVETLRQDRGVANIPAESYLKASDAPD LQKPDKALQSPPPASTDPATMLSGNAGEGATACGGSAAAGQDLISVPRNTFMTLLQTNLD NKPPRQTPLPYAAPLPPFSHQAIATAPSYGPGAGAVAPAGGYFTSPGGYYAGPAGGDPGA FLAMDAHTYHPHPHPPPAYFGLPGLFGPPPPVPPYYGSHLRADYVPAPSRSNKRKRDPEE DEEGGGLFPGEDATLYRKDIAGLSKSVNELQHTLQALRRETLSYGHTGVGYCPQQGPCYT HSGPYGFQPHQSYEVPRYVPHPPPPPTSHQAAQAQPPPPGTQAPEAHCVAESTIPEAGAA GNSGPREDTNPQQPTTEGHHRGKKLVQASASGVAQSKEPTTPKAKSVSAHLKSIFCEELL NKRVA
- Number of residues
- 605
- Molecular Weight
- 64101.37
- Theoretical pI
- 6.79
- GO Classification
- Functionsserine-type endopeptidase activityProcessesviral release from host cellComponentshost cell cytoplasm / host cell nucleus
- General Function
- Capsid scaffolding protein Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.
- Specific Function
- identical protein binding
- Pfam Domain Function
- Peptidase_S21 (PF00716)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Host cytoplasm
- Gene sequence
>lcl|BSEQ0021311|Capsid scaffolding protein ATGCTATCAGGTAACGCAGGAGAAGGAGCAACAGCCTGCGGAGGTTCGGCCGCCGCGGGC CAGGACCTCATCAGCGTCCCCCGCAACACCTTTATGACACTGCTTCAGACCAACCTGGAC AACAAACCGCCGAGGCAGACCCCGCTACCCTACGCGGCCCCGCTGCCCCCCTTTTCCCAC CAGGCAATAGCCACCGCGCCTTCCTACGGTCCTGGGGCCGGAGCGGTCGCCCCGGCCGGC GGCTACTTTACCTCCCCAGGAGGTTACTACGCCGGGCCCGCGGGCGGGGACCCGGGTGCC TTCTTGGCGATGGACGCTCACACCTACCACCCCCACCCACACCCCCCTCCGGCCTACTTT GGCTTGCCGGGCCTCTTTGGCCCCCCTCCACCCGTGCCTCCTTACTACGGATCCCACTTG CGGGCAGACTACGTCCCCGCTCCCTCGCGATCCAACAAGCGGAAAAGAGACCCCGAGGAG GATGAAGAAGGCGGGGGGCTATTCCCGGGGGAGGACGCCACCCTCTACCGCAAGGACATA GCGGGCCTCTCCAAGAGTGTGAATGAGTTACAGCACACGCTACAGGCCCTGCGCCGGGAG ACGCTGTCCTACGGCCACACCGGAGTCGGATACTGCCCCCAGCAGGGCCCCTGCTACACC CACTCGGGGCCTTACGGATTTCAGCCTCATCAAAGCTACGAAGTGCCCAGATACGTCCCT CATCCGCCCCCACCACCAACTTCTCACCAGGCAGCTCAGGCGCAGCCTCCACCCCCGGGC ACACAGGCCCCCGAAGCCCACTGTGTGGCCGAGTCCACGATCCCTGAGGCGGGAGCAGCC GGGAACTCTGGACCCCGGGAGGACACCAACCCTCAGCAGCCCACCACCGAGGGCCACCAC CGCGGAAAGAAACTGGTGCAGGCCTCTGCGTCCGGAGTGGCTCAGTCTAAGGAGCCCACC ACCCCCAAGGCCAAGTCTGTGTCAGCCCACCTCAAGTCCATCTTTTGCGAGGAATTGCTG AATAAACGCGTGGCTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P03234 UniProtKB Entry Name SCAF_EBVB9 GenBank Protein ID 1334909 GenBank Gene ID V01555 PDB ID(s) 1O6E KEGG ID vg:3783696 NCBI Gene ID 3783733 - General References
- Bankier AT, Deininger PL, Farrell PJ, Barrell BG: Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8 Epstein-Barr virus. Mol Biol Med. 1983 Jul;1(1):21-45. [Article]
- Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, et al.: DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature. 1984 Jul 19-25;310(5974):207-11. [Article]
- Henson BW, Perkins EM, Cothran JE, Desai P: Self-assembly of Epstein-Barr virus capsids. J Virol. 2009 Apr;83(8):3877-90. doi: 10.1128/JVI.01733-08. Epub 2009 Jan 21. [Article]
- Buisson M, Hernandez JF, Lascoux D, Schoehn G, Forest E, Arlaud G, Seigneurin JM, Ruigrok RW, Burmeister WP: The crystal structure of the Epstein-Barr virus protease shows rearrangement of the processed C terminus. J Mol Biol. 2002 Nov 15;324(1):89-103. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Phosphorylisopropane experimental unknown target Details