Lipid A palmitoyltransferase PagP

BE0001965ProteinEscherichia coli (strain K12)pagP

Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. It is acted on by 2 drugs in DrugBank.

Gene name
pagP
UniProtKB entry
P37001Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
186 residues · 21,769 Da
Also known as
2.3.1.- · 2.3.1.251 · Antimicrobial peptide resistance · crcA · Lipid A acylation protein

Resolves to

Protein
UniProtP37001UniProt namePAGP_ECOLI
Gene
NCBI Gene946360GenBank26986711
Pharmacology
KEGGecj:JW0617
Structure
PDB1MM4PDB1MM5PDB1THQ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Lipid A palmitoyltransferase PagP, and which indications are they being tested in?

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