dTDP-4-dehydrorhamnose reductase

BE0001971ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)rfbD

Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). It is acted on by 1 drug in DrugBank.

Gene name
rfbD
UniProtKB entry
P26392Swiss-Prot
Residues / weight
299 residues · 32,554 Da
Also known as
1.1.1.133 · dTDP-4-keto-L-rhamnose reductase · dTDP-6-deoxy-L-lyxo-4-hexulose reductase · dTDP-6-deoxy-L-mannose dehydrogenase · dTDP-L-rhamnose synthase

Resolves to

Protein
UniProtP26392UniProt nameRMLD_SALTY
Gene
NCBI Gene1253617
Pharmacology
KEGGstm:STM2096
Structure
PDB1KBZPDB1KC1PDB1KC3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on dTDP-4-dehydrorhamnose reductase, and which indications are they being tested in?

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