Uracil phosphoribosyltransferase

BE0001973ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)upp

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. It is acted on by 1 drug in DrugBank.

Gene name
upp
UniProtKB entry
Q9WZI0Swiss-Prot
Residues / weight
209 residues · 23,320 Da
Also known as
2.4.2.9 · UMP pyrophosphorylase · UPRTase

Resolves to

Protein
UniProtQ9WZI0UniProt nameUPP_THEMA
Gene
NCBI Gene898388GenBank4981245
Pharmacology
KEGGtma:TM0721
Structure
PDB1O5O
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Uracil phosphoribosyltransferase, and which indications are they being tested in?

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