Cytidine deaminase

Details

Name
Cytidine deaminase
Kind
protein
Synonyms
  • 3.5.4.5
  • CDA
  • Cytidine aminohydrolase
Gene Name
cdd
UniProtKB Entry
P19079Swiss-Prot
Organism
Bacillus subtilis (strain 168)
NCBI Taxonomy ID
224308
Amino acid sequence
>lcl|BSEQ0011426|Cytidine deaminase
MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIENAAYSMCNCAERTALF
KAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVIVVLTNLQGQIKEMTVEEL
LPGAFSSEDLHDERKL
Number of residues
136
Molecular Weight
14853.885
Theoretical pI
4.62
GO Classification
Functions
cytidine deaminase activity / zinc ion binding
General Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Specific Function
cytidine deaminase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011427|Cytidine deaminase (cdd)
ATGAACAGACAAGAATTAATAACAGAAGCTTTAAAAGCGCGTGATATGGCATATGCGCCG
TATTCCAAATTCCAAGTAGGAGCCGCTCTTCTTACCAAGGATGGAAAAGTGTACAGAGGC
TGCAATATTGAGAACGCGGCATACAGCATGTGCAATTGCGCCGAGCGTACCGCTTTATTT
AAAGCTGTTTCTGAAGGGGATACAGAGTTTCAGATGCTGGCCGTTGCGGCTGACACCCCT
GGACCAGTATCTCCGTGCGGAGCCTGCCGACAGGTGATTTCTGAGCTTTGCACAAAAGAC
GTTATTGTCGTACTGACTAATTTACAAGGACAAATAAAAGAAATGACTGTGGAAGAATTA
TTGCCAGGCGCATTTTCATCGGAGGATTTACATGACGAACGAAAGCTTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP19079
UniProtKB Entry NameCDD_BACSU
GenBank Protein ID606744
GenBank Gene IDU18532
PDB ID(s)1JTK, 1UWZ, 1UX0, 1UX1
KEGG IDbsu:BSU25300
NCBI Gene ID937885
General References
  1. Song BH, Neuhard J: Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase. Mol Gen Genet. 1989 Apr;216(2-3):462-8. [Article]
  2. Mizuno M, Masuda S, Takemaru K, Hosono S, Sato T, Takeuchi M, Kobayashi Y: Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes. Microbiology. 1996 Nov;142 ( Pt 11):3103-11. [Article]
  3. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  4. Johansson E, Mejlhede N, Neuhard J, Larsen S: Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution. Biochemistry. 2002 Feb 26;41(8):2563-70. [Article]
  5. Johansson E, Neuhard J, Willemoes M, Larsen S: Structural, kinetic, and mutational studies of the zinc ion environment in tetrameric cytidine deaminase. Biochemistry. 2004 May 25;43(20):6020-9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
TetrahydrodeoxyuridineexperimentalunknowntargetDetails