Cytidine deaminase
Details
- Name
- Cytidine deaminase
- Kind
- protein
- Synonyms
- 3.5.4.5
- CDA
- Cytidine aminohydrolase
- Gene Name
- cdd
- UniProtKB Entry
- P19079Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0011426|Cytidine deaminase MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIENAAYSMCNCAERTALF KAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVIVVLTNLQGQIKEMTVEEL LPGAFSSEDLHDERKL
- Number of residues
- 136
- Molecular Weight
- 14853.885
- Theoretical pI
- 4.62
- GO Classification
- Functionscytidine deaminase activity / zinc ion binding
- General Function
- This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
- Specific Function
- cytidine deaminase activity
- Pfam Domain Function
- dCMP_cyt_deam_1 (PF00383)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0011427|Cytidine deaminase (cdd) ATGAACAGACAAGAATTAATAACAGAAGCTTTAAAAGCGCGTGATATGGCATATGCGCCG TATTCCAAATTCCAAGTAGGAGCCGCTCTTCTTACCAAGGATGGAAAAGTGTACAGAGGC TGCAATATTGAGAACGCGGCATACAGCATGTGCAATTGCGCCGAGCGTACCGCTTTATTT AAAGCTGTTTCTGAAGGGGATACAGAGTTTCAGATGCTGGCCGTTGCGGCTGACACCCCT GGACCAGTATCTCCGTGCGGAGCCTGCCGACAGGTGATTTCTGAGCTTTGCACAAAAGAC GTTATTGTCGTACTGACTAATTTACAAGGACAAATAAAAGAAATGACTGTGGAAGAATTA TTGCCAGGCGCATTTTCATCGGAGGATTTACATGACGAACGAAAGCTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P19079 UniProtKB Entry Name CDD_BACSU GenBank Protein ID 606744 GenBank Gene ID U18532 PDB ID(s) 1JTK, 1UWZ, 1UX0, 1UX1 KEGG ID bsu:BSU25300 NCBI Gene ID 937885 - General References
- Song BH, Neuhard J: Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase. Mol Gen Genet. 1989 Apr;216(2-3):462-8. [Article]
- Mizuno M, Masuda S, Takemaru K, Hosono S, Sato T, Takeuchi M, Kobayashi Y: Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes. Microbiology. 1996 Nov;142 ( Pt 11):3103-11. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Johansson E, Mejlhede N, Neuhard J, Larsen S: Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution. Biochemistry. 2002 Feb 26;41(8):2563-70. [Article]
- Johansson E, Neuhard J, Willemoes M, Larsen S: Structural, kinetic, and mutational studies of the zinc ion environment in tetrameric cytidine deaminase. Biochemistry. 2004 May 25;43(20):6020-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Tetrahydrodeoxyuridine experimental unknown target Details