4-hydroxy-tetrahydrodipicolinate reductase

BE0001983ProteinMycobacterium tuberculosisdapB

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). It is acted on by 1 drug in DrugBank.

Gene name
dapB
UniProtKB entry
P9WP23Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
245 residues · 25,733 Da
Also known as
1.17.1.8 · HTPA reductase

Resolves to

Protein
UniProtP9WP23UniProt nameDAPB_MYCTU
Gene
NCBI Gene888443
Pharmacology
KEGGmtu:Rv2773c
Structure
PDB1C3VPDB1P9LPDB1YL5
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-hydroxy-tetrahydrodipicolinate reductase, and which indications are they being tested in?

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