4-hydroxy-tetrahydrodipicolinate reductase

BE0001986ProteinEscherichia coli (strain K12)dapB

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. It is acted on by 2 drugs in DrugBank.

Gene name
dapB
UniProtKB entry
P04036Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
273 residues · 28,756 Da
Also known as
1.17.1.8 · HTPA reductase

Resolves to

Protein
UniProtP04036UniProt nameDAPB_ECOLI
Gene
NCBI Gene944762GenBank145710
Pharmacology
KEGGecj:JW0029
Structure
PDB1ARZPDB1DIHPDB1DRU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-hydroxy-tetrahydrodipicolinate reductase, and which indications are they being tested in?

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