Endo-N-acetylneuraminidase
Details
- Name
- Endo-N-acetylneuraminidase
- Kind
- protein
- Synonyms
- 3.2.1.129
- Endo-N
- Endosialidase
- G102
- Gene Name
- Not Available
- UniProtKB Entry
- Q04830Swiss-Prot
- Organism
- Enterobacteria phage K1F
- NCBI Taxonomy ID
- 344021
- Amino acid sequence
>lcl|BSEQ0011436|Endo-N-acetylneuraminidase MSTITQFPSGNTQYRIEFDYLARTFVVVTLVNSSNPTLNRVLEVGRDYRFLNPTMIEMLV DQSGFDIVRIHRQTGTDLVVDFRNGSVLTASDLTTAELQAIHIAEEGRDQTVDLAKEYAD AAGSSAGNAKDSEDEARRIAESIRAAGLIGYMTRRSFEKGYNVTTWSEVLLWEEDGDYYR WDGTLPKNVPAGSTPETSGGIGLGAWVSVGDAALRSQISNPEGAILYPELHRARWLDEKD ARGWGAKGDGVTDDTAALTSALNDTPVGQKINGNGKTYKVTSLPDISRFINTRFVYERIP GQPLYYASEEFVQGELFKITDTPYYNAWPQDKAFVYENVIYAPYMGSDRHGVSRLHVSWV KSGDDGQTWSTPEWLTDLHPDYPTVNYHCMSMGVCRNRLFAMIETRTLAKNALTNCALWD RPMSRSLHLTGGITKAANQRYATIHVPDHGLFVGDFVNFSNSAVTGVSGDMTVATVIDKD NFTVLTPNQQTSDLNNAGKNWHMGTSFHKSPWRKTDLGLIPSVTEVHSFATIDNNGFAMG YHQGDVAPREVGLFYFPDAFNSPSNYVRRQIPSEYEPDASEPCIKYYDGVLYLITRGTRG DRLGSSLHRSRDIGQTWESLRFPHNVHRTTLPFAKVGDDLIMFGSERAENEWEAGAPDDR YKASYPRTFYARLNVNNWNADDIEWVNITDQIYQGGIVNSGVGVGSVVVKDNYIYYMFGG EDHFNPWTYGDNSAKDPFKSDGHPSDLYCYKMKIGPDNRVSRDFRYGAVPNRAVPVFFDT NGVRTVPAPMEFTGDLGLGHVTIRASTSSNIRSEVLMEGEYGFIGKSIPTDNPAGQRIIF CGGEGTSSTTGAQITLYGANNTDSRRIVYNGDEHLFQSADVKPYNDNVTALGGPSNRFTT AYLGSNPIVTSNGGGGKQSR
- Number of residues
- 920
- Molecular Weight
- 102012.495
- Theoretical pI
- 5.37
- GO Classification
- Functionsendo-alpha-(2,8)-sialidase activity
- General Function
- Mature tail spike protein Receptor binding protein, which mediates the attachment to the host capsule (PubMed:20096705, PubMed:3546309). Degrades the alpha-2,8-linked polysialic acid of E.coli K1 capsule by cleaving within the polymer chain of polysialic acid (PubMed:3546309).
- Specific Function
- endo-alpha-(2,8)-sialidase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003945|2763 bp ATGTCCACGATTACACAATTCCCTTCAGGAAACACTCAGTACAGGATTGAGTTCGACTAC CTAGCCAGAACGTTTGTTGTTGTTACGCTGGTGAATAGCTCTAACCCTACCCTGAACCGT GTACTGGAAGTTGGTCGAGATTACCGATTCCTTAACCCAACGATGATTGAGATGTTGGTG GACCAATCAGGTTTCGACATCGTTCGTATTCACCGTCAGACTGGGACTGACTTAGTGGTA GACTTCAGGAATGGCTCAGTGTTGACAGCTAGTGACCTGACCACTGCAGAGCTTCAGGCT ATCCATATTGCAGAAGAAGGTCGAGACCAAACGGTTGACTTAGCGAAGGAATATGCCGAT GCTGCTGGTAGCTCTGCTGGCAACGCTAAGGATAGCGAGGACGAAGCACGACGAATCGCT GAGAGTATCAGGGCAGCTGGTCTAATTGGTTATATGACCCGTCGCTCCTTCGAGAAAGGC TACAACGTTACAACATGGAGCGAGGTCCTGCTATGGGAAGAGGATGGTGATTATTACCGC TGGGATGGTACGCTTCCAAAGAACGTTCCTGCTGGTTCAACTCCTGAAACTTCCGGTGGG ATTGGATTAGGTGCGTGGGTTAGTGTTGGTGATGCTGCTTTAAGAAGTCAGATTTCAAAC CCGGAAGGGGCAATACTCTACCCTGAATTACATAGAGCACGCTGGCTTGATGAAAAAGAT GCTCGTGGTTGGGGTGCTAAAGGGGATGGTGTCACTGATGATACAGCAGCGTTAACGAGC GCATTAAACGACACACCGGTTGGACAAAAGATTAATGGCAATGGGAAGACATATAAGGTC ACATCCCTGCCTGACATTAGTCGCTTCATCAACACTCGTTTCGTTTATGAGCGCATTCCC GGACAACCTCTTTATTATGCCTCTGAAGAATTTGTTCAGGGTGAGCTATTCAAAATAACG GACACCCCTTATTACAATGCGTGGCCTCAGGATAAAGCGTTCGTATATGAGAATGTGATA TATGCACCTTACATGGGTAGCGATCGTCATGGTGTTAGTCGTCTGCATGTATCATGGGTT AAGTCTGGTGATGATGGTCAAACATGGTCTACTCCAGAGTGGTTAACTGATCTGCATCCA GATTACCCTACAGTGAACTATCATTGTATGAGTATGGGTGTATGTCGCAACCGTCTGTTT GCCATGATTGAAACACGTACCTTAGCCAAGAACGCATTAACCAATTGTGCATTGTGGGAT CGCCCCATGTCTCGTAGCCTGCATCTTACTGGTGGTATCACTAAAGCTGCAAATCAGCGA TATGCAACAATACATGTACCAGACCACGGACTATTCGTGGGTGATTTTGTTAACTTCTCT AATTCTGCGGTAACAGGTGTATCCGGTGATATGACTGTTGCAACCGTAATAGATAAGGAC AACTTCACGGTTCTTACACCCAACCAGCAGACTTCAGATTTGAATAACGCTGGAAAGAAT TGGCACATGGGTACTTCTTTCCATAAGTCTCCATGGCGTAAGACAGATCTTGGTCTAATC CCTAGTGTCACAGAGGTGCATAGCTTTGCTACTATTGATAACAATGGCTTTGCTATGGGC TATCATCAAGGTGATGTAGCTCCACGAGAAGTTGGGCTTTTCTACTTCCCTGATGCTTTC AATAGCCCATCTAATTATGTTCGTCGTCAGATACCATCTGAGTATGAACCAGATGCGTCA GAGCCGTGCATCAAGTACTATGACGGTGTATTATACCTTATCACTCGTGGCACTCGTGGT GATAGACTAGGTAGCTCTTTGCATCGTAGTAGAGACATAGGTCAGACTTGGGAGTCACTG AGATTTCCACATAATGTTCATCGTACTACATTACCTTTTGCTAAAGTAGGGGATGACCTT ATTATGTTTGGTTCAGAACGTGCAGAAAATGAATGGGAAGCAGGTGCACCAGATGATCGT TACAAGGCATCTTATCCTCGCACCTTCTATGCACGCTTGAATGTAAACAATTGGAATGCA GATGATATTGAATGGGTTAACATCACTGACCAGATTTATCAGGGCGGAATAGTTAACTCA GGTGTAGGTGTTGGTTCGGTAGTTGTGAAGGATAATTACATCTACTACATGTTTGGTGGA GAGGACCATTTTAACCCATGGACATATGGAGATAACTCAGCGAAAGACCCATTCAAATCG GATGGTCACCCCTCGGATTTGTATTGCTACAAAATGAAGATTGGCCCAGACAATCGTGTT TCCAGAGATTTCAGATATGGTGCTGTACCCAACAGAGCTGTTCCCGTGTTTTTTGATACG AATGGGGTTCGCACTGTTCCTGCGCCAATGGAATTTACAGGGGATTTGGGTTTAGGTCAT GTGACCATTAGAGCCAGCACCAGTAGTAACATTCGCTCTGAAGTTTTAATGGAAGGTGAA TATGGGTTTATCGGGAAATCTATACCGACTGATAACCCGGCAGGGCAGCGCATCATATTT TGCGGGGGTGAAGGCACCAGTTCAACGACTGGCGCACAGATTACGCTATATGGTGCAAAT AACACCGACTCAAGGCGAATAGTTTACAACGGAGATGAGCATCTATTTCAGAGTGCTGAT GTTAAGCCTTATAACGATAACGTCACTGCGCTTGGTGGGCCTAGCAACCGTTTCACCACT GCATACCTCGGAAGCAACCCTATTGTTACTTCTAACGGGGGAGGAGGAAAACAGAGCCGG TAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q04830 UniProtKB Entry Name ENAN_BPK1F PDB ID(s) 1V0E, 1V0F, 3GVJ, 3GVK, 3GVL, 3GW6, 3JU4 - General References
- Petter JG, Vimr ER: Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo-N-acylneuraminidase (endo-N) and comparison to an endo-N homolog in bacteriophage PK1E. J Bacteriol. 1993 Jul;175(14):4354-63. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-acetyl-alpha-neuraminic acid experimental unknown target Details N-acetyl-beta-neuraminic acid experimental unknown target Details