Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive

BE0002004ProteinEscherichia coli (strain K12)aroG

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). It is acted on by 2 drugs in DrugBank.

Gene name
aroG
UniProtKB entry
P0AB91Swiss-Prot
Residues / weight
350 residues · 38,009 Da
Also known as
2.5.1.54 · 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase · DAHP synthase · Phospho-2-keto-3-deoxyheptonate aldolase

Resolves to

Protein
UniProtP0AB91UniProt nameAROG_ECOLI
Gene
NCBI Gene945605GenBank145368
Pharmacology
KEGGecj:JW0737
Structure
PDB1GG1PDB1KFLPDB1N8F
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive, and which indications are they being tested in?

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