Penicillin-insensitive murein endopeptidase

BE0002005ProteinEscherichia coli (strain K12)mepA

Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands. It is acted on by 1 drug in DrugBank.

Gene name
mepA
UniProtKB entry
P0C0T5Swiss-Prot
Cellular location
Periplasm
Residues / weight
274 residues · 30,136 Da
Also known as
3.4.24.- · D-alanyl-D-alanine-endopeptidase · DD-endopeptidase

Resolves to

Protein
UniProtP0C0T5UniProt nameMEPA_ECOLI
Gene
NCBI Gene946812GenBank41993
Pharmacology
KEGGecj:JW2325
Structure
PDB1TZPPDB1U10
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
7+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Penicillin-insensitive murein endopeptidase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In