5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

BE0002007ProteinEscherichia coli (strain K12)mtnN

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (PubMed:16101288, PubMed:3911944). It is acted on by 5 drugs in DrugBank.

Gene name
mtnN
UniProtKB entry
P0AF12Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
232 residues · 24,354 Da
Also known as
3.2.2.9 · 5'-deoxyadenosine nucleosidase · 5'-methylthioadenosine nucleosidase · AdoHcy nucleosidase · dAdo nucleosidase

Resolves to

Protein
UniProtP0AF12UniProt nameMTNN_ECOLI
Gene
NCBI Gene948542GenBank2981267
Pharmacology
KEGGecj:JW0155
Structure
PDB1JYSPDB1NC1PDB1NC3
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In