Acyl-CoA thioesterase 2

BE0002038ProteinEscherichia coli (strain K12)tesB

Thioesterase that has relatively broad substrate specificity, hydrolyzing primarily medium- and long-chain acyl-CoA substrates to free fatty acids and CoA (PubMed:1645722, PubMed:20547355, PubMed:24271180). It is acted on by 1 drug in DrugBank.

Gene name
tesB
UniProtKB entry
P0AGG2Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
286 residues · 31,966 Da
Also known as
3.1.2.- · 3.1.2.20 · Acyl-CoA thioesterase II · TEII · Thioesterase II

Resolves to

Protein
UniProtP0AGG2UniProt nameTESB_ECOLI
Gene
NCBI Gene945074GenBank147932
Pharmacology
KEGGecj:JW0442
Structure
PDB1C8U
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Acyl-CoA thioesterase 2, and which indications are they being tested in?

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