Amidophosphoribosyltransferase

BE0002042ProteinEscherichia coli (strain K12)purF

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. It is acted on by 3 drugs in DrugBank.

Gene name
purF
UniProtKB entry
P0AG16Swiss-Prot
Residues / weight
505 residues · 56,487 Da
Also known as
2.4.2.14 · ATase · Glutamine phosphoribosylpyrophosphate amidotransferase · GPATase

Resolves to

Protein
UniProtP0AG16UniProt namePUR1_ECOLI
Gene
NCBI Gene946794GenBank42593
Pharmacology
KEGGecj:JW2309
Structure
PDB1ECBPDB1ECCPDB1ECF
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Amidophosphoribosyltransferase, and which indications are they being tested in?

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