Inosine-5'-monophosphate dehydrogenase

BE0002047ProteinStreptococcus pyogenesguaB

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of... It is acted on by 2 drugs in DrugBank.

Gene name
guaB
UniProtKB entry
P0C0H6Swiss-Prot
Residues / weight
493 residues · 52,807 Da
Also known as
1.1.1.205 · IMP dehydrogenase · impD

Resolves to

Protein
UniProtP0C0H6UniProt nameIMDH_STRPY
Gene
GenBank924848
Structure
PDB1ZFJ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Inosine-5'-monophosphate dehydrogenase, and which indications are they being tested in?

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