D-tagatose-1,6-bisphosphate aldolase subunit KbaY

BE0002054ProteinEscherichia coli (strain K12)kbaY

Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). It is acted on by 1 drug in DrugBank.

Gene name
kbaY
UniProtKB entry
P0AB74Swiss-Prot
Residues / weight
286 residues · 31,293 Da
Also known as
4.1.2.40 · agaY · D-tagatose-bisphosphate aldolase class II · kba · Ketose 1,6-bisphosphate aldolase class II

Resolves to

Protein
UniProtP0AB74UniProt nameKBAY_ECOLI
Gene
NCBI Gene947644
Pharmacology
KEGGecj:JW3106
Structure
PDB1GVF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on D-tagatose-1,6-bisphosphate aldolase subunit KbaY, and which indications are they being tested in?

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