Sensor histidine kinase EnvZ

BE0002079ProteinEscherichia coli (strain K12)envZ

Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:2997120, PubMed:3536870). It is acted on by 1 drug in DrugBank.

Gene name
envZ
UniProtKB entry
P0AEJ4Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
450 residues · 50,334 Da
Also known as
2.7.13.3 · ompB · Osmolarity sensor protein EnvZ · perA · tpo

Resolves to

Protein
UniProtP0AEJ4UniProt nameENVZ_ECOLI
Gene
NCBI Gene947272
Pharmacology
KEGGecj:JW3367
Structure
PDB1BXDPDB1JOYPDB1NJV
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Sensor histidine kinase EnvZ, and which indications are they being tested in?

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