Hypoxanthine phosphoribosyltransferase

BE0002080ProteinEscherichia coli (strain K12)hpt

Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). It is acted on by 1 drug in DrugBank.

Gene name
hpt
UniProtKB entry
P0A9M2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
178 residues · 20,115 Da
Also known as
2.4.2.8 · 6-oxopurine phosphoribosyltransferase · 6-oxopurine PRTase · HPRT

Resolves to

Protein
UniProtP0A9M2UniProt nameHPRT_ECOLI
Gene
NCBI Gene946624
Pharmacology
KEGGecj:JW5009
Structure
PDB1G9SPDB1G9TPDB1GRV
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Hypoxanthine phosphoribosyltransferase, and which indications are they being tested in?

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