Keratin, type II cytoskeletal 8

BE0002105ProteinHumansKRT8

Structural component of intermediate filaments in simple epithelial cells. It is acted on by 2 drugs in DrugBank.

Gene name
KRT8
UniProtKB entry
P05787Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
483 residues · 53,704 Da
Also known as
CK-8 · CYK8 · Cytokeratin-8 · K8 · Keratin-8

Resolves to

Protein
UniProtP05787UniProt nameK2C8_HUMAN
Gene
HGNCHGNC:6446NCBI Gene3856GenBank181573GeneCardsKRT8
Pharmacology
KEGGhsa:3856
Structure
PDB7K3CPDB7K3XPDB7K3Y
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Keratin, type II cytoskeletal 8, how selective are they, and which programs against it are still in active trials?

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