Retinoblastoma-associated protein

BE0002123ProteinHumansRB1

Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). It is acted on by 1 drug in DrugBank.

Gene name
RB1
UniProtKB entry
P06400Swiss-Prot
Cellular location
Nucleus
Residues / weight
928 residues · 106,158 Da
Also known as
p105-Rb · p110-RB1 · pp110 · pRb · Rb

Resolves to

Protein
UniProtP06400UniProt nameRB_HUMAN
Gene
HGNCHGNC:9884NCBI Gene5925GenBank190959GeneCardsRB1
Pharmacology
KEGGhsa:5925
Structure
PDB1AD6PDB1GH6PDB1GUX
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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16Clinical trialsTrials of drugs acting on it, by phase and status
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32GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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80+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Retinoblastoma-associated protein, and which indications are they being tested in?

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