Neuroendocrine convertase 2

BE0002124ProteinHumansPCSK2

Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (PubMed:28719828, PubMed:7626024, PubMed:8879041, PubMed:9287128). It is acted on by 2 drugs in DrugBank.

Gene name
PCSK2
UniProtKB entry
P16519Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle
Residues / weight
638 residues · 70,565 Da
Also known as
3.4.21.94 · KEX2-like endoprotease 2 · NEC 2 · NEC2 · PC2

Resolves to

Protein
UniProtP16519UniProt nameNEC2_HUMAN
Gene
HGNCHGNC:8744NCBI Gene5126GenBank189652GeneCardsPCSK2
Pharmacology
IUPHAR/GtoPdb2383KEGGhsa:5126
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuroendocrine convertase 2, how selective are they, and which programs against it are still in active trials?

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