Neuropilin-1

BE0002129ProteinHumansNRP1

Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It is acted on by 4 drugs in DrugBank.

Gene name
NRP1
UniProtKB entry
O14786Swiss-Prot
Cellular location
Secreted
Residues / weight
923 residues · 103,134 Da
Also known as
NRP · Vascular endothelial cell growth factor 165 receptor · VEGF165R

Resolves to

Protein
UniProtO14786UniProt nameNRP1_HUMAN
Gene
HGNCHGNC:8004NCBI Gene8829GenBank2407641GeneCardsNRP1
Pharmacology
IUPHAR/GtoPdb2998KEGGhsa:8829
Structure
PDB1KEXPDB2QQIPDB2QQM
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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35GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuropilin-1, how selective are they, and which programs against it are still in active trials?

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