Kynurenine--oxoglutarate transaminase 3

BE0002162ProteinHumansKYAT3

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid... It is acted on by 1 drug in DrugBank.

Gene name
KYAT3
UniProtKB entry
Q6YP21Swiss-Prot
Residues / weight
454 residues · 51,400 Da
Also known as
2.6.1.7 · CCBL2 · Cysteine-S-conjugate beta-lyase 2 · KAT3 · KATIII

Resolves to

Protein
UniProtQ6YP21UniProt nameKAT3_HUMAN
Gene
HGNCHGNC:33238NCBI Gene56267GenBank37542047GeneCardsKYAT3
Pharmacology
KEGGhsa:56267
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kynurenine--oxoglutarate transaminase 3, how selective are they, and which programs against it are still in active trials?

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