Acidic amino acid decarboxylase GADL1

BE0002163ProteinHumansGADL1

May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. It is acted on by 1 drug in DrugBank.

Gene name
GADL1
UniProtKB entry
Q6ZQY3Swiss-Prot
Residues / weight
521 residues · 59,246 Da
Also known as
ADC · Aspartate 1-decarboxylase · CSADC · Cysteine sulfinic acid decarboxylase · Glutamate decarboxylase-like protein 1

Resolves to

Protein
UniProtQ6ZQY3UniProt nameGADL1_HUMAN
Gene
HGNCHGNC:27949NCBI Gene339896GenBank34536121GeneCardsGADL1
Pharmacology
KEGGhsa:339896
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acidic amino acid decarboxylase GADL1, how selective are they, and which programs against it are still in active trials?

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