Serine dehydratase-like

BE0002168ProteinHumansSDSL

Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively (PubMed:16580895, PubMed:18342636). It is acted on by 1 drug in DrugBank.

Gene name
SDSL
UniProtKB entry
Q96GA7Swiss-Prot
Residues / weight
329 residues · 34,674 Da
Also known as
Cancerous serine dehydratase · cSDH · Glutamate racemase · L-serine deaminase · L-serine dehydratase/L-threonine deaminase

Resolves to

Protein
UniProtQ96GA7UniProt nameSDSL_HUMAN
Gene
HGNCHGNC:30404NCBI Gene113675GenBank33150744GeneCardsSDSL
Pharmacology
KEGGhsa:113675
Structure
PDB2RKB
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine dehydratase-like, how selective are they, and which programs against it are still in active trials?

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