O-phosphoseryl-tRNA(Sec) selenium transferase

BE0002171ProteinHumansSEPSECS

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. It is acted on by 1 drug in DrugBank.

Gene name
SEPSECS
UniProtKB entry
Q9HD40Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
501 residues · 55,726 Da
Also known as
2.9.1.2 · Liver-pancreas antigen · LP · Sec synthase · Selenocysteine synthase

Resolves to

Protein
UniProtQ9HD40UniProt nameSPCS_HUMAN
Gene
HGNCHGNC:30605NCBI Gene51091GenBank7652498GeneCardsSEPSECS
Pharmacology
KEGGhsa:51091
Structure
PDB3HL2PDB4ZDLPDB4ZDO
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on O-phosphoseryl-tRNA(Sec) selenium transferase, how selective are they, and which programs against it are still in active trials?

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