Serine palmitoyltransferase 3

BE0002172ProteinHumansSPTLC3

Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851, PubMed:19648650). It is acted on by 1 drug in DrugBank.

Gene name
SPTLC3
UniProtKB entry
Q9NUV7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
552 residues · 62,049 Da
Also known as
2.3.1.50 · C20orf38 · LCB 3 · LCB2b · Long chain base biosynthesis protein 2b

Resolves to

Protein
UniProtQ9NUV7UniProt nameSPTC3_HUMAN
Gene
HGNCHGNC:16253NCBI Gene55304GenBank7023574GeneCardsSPTLC3
Pharmacology
KEGGhsa:55304
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine palmitoyltransferase 3, how selective are they, and which programs against it are still in active trials?

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