Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

BE0002225ProteinHumansPAICS

Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. It is acted on by 1 drug in DrugBank.

Gene name
PAICS
UniProtKB entry
P22234Swiss-Prot
Residues / weight
425 residues · 47,079 Da
Also known as
ADE2 · AIRC · PAICS · PAIS

Resolves to

Protein
UniProtP22234UniProt namePUR6_HUMAN
Gene
HGNCHGNC:8587NCBI Gene10606GenBank28384GeneCardsPAICS
Pharmacology
KEGGhsa:10606
Structure
PDB2H31PDB6YB8PDB6YB9
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, how selective are they, and which programs against it are still in active trials?

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